This paper deals with problems that have to be faced when performing mass and temperature measurements of substances subjected to freeze-drying processes. A brief description of a lyophilization process is initially presented and a deep investigation is performed in order to identify the main uncertainty contributions that affect mass and temperature measurements. A measurement system is then described that has been specifically conceived to work inside a freeze-dryer. Experimental results are reported that refer to the metrological characterization of the proposed measurement system and to its use for the monitoring of real freeze-drying processes. Experimental tests are also described that have been conceived to estimate the uncertainty contributions strictly related to this specific application.

Measurement uncertainty issues in freeze-drying Processes / Carullo, Alessio; Vallan, Alberto. - In: MEASUREMENT. - ISSN 0263-2241. - STAMPA. - 45:7(2012), pp. 1706-1712. [10.1016/j.measurement.2012.04.017]

Measurement uncertainty issues in freeze-drying Processes

CARULLO, Alessio;VALLAN, Alberto
2012

Abstract

This paper deals with problems that have to be faced when performing mass and temperature measurements of substances subjected to freeze-drying processes. A brief description of a lyophilization process is initially presented and a deep investigation is performed in order to identify the main uncertainty contributions that affect mass and temperature measurements. A measurement system is then described that has been specifically conceived to work inside a freeze-dryer. Experimental results are reported that refer to the metrological characterization of the proposed measurement system and to its use for the monitoring of real freeze-drying processes. Experimental tests are also described that have been conceived to estimate the uncertainty contributions strictly related to this specific application.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2497099
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