The continuing discovery of new functions and classes of small non-coding RNAs is suggesting the presence of regulatory mechanisms far more complex than the ones identified so far. In our computational analysis of a large set of public available databases, we found statistical evidence of an inter-pathway regulatory motif, not previously described, that reveals a new protective role miRNAs may play in the successful activation of a pathway. This paper reports the main outcomes of this analysis.

A New miRNA Motif Protects Pathways’ Expression in Gene Regulatory Networks / Benso, Alfredo; DI CARLO, Stefano; Politano, GIANFRANCO MICHELE MARIA; Savino, Alessandro. - STAMPA. - (2013), pp. 377-384. (Intervento presentato al convegno International Work-Conference on Bioinformatics and Biomedical Engineering (IWBBIO) tenutosi a Granada, ES nel 18-20 March , 2013).

A New miRNA Motif Protects Pathways’ Expression in Gene Regulatory Networks

BENSO, Alfredo;DI CARLO, STEFANO;POLITANO, GIANFRANCO MICHELE MARIA;SAVINO, ALESSANDRO
2013

Abstract

The continuing discovery of new functions and classes of small non-coding RNAs is suggesting the presence of regulatory mechanisms far more complex than the ones identified so far. In our computational analysis of a large set of public available databases, we found statistical evidence of an inter-pathway regulatory motif, not previously described, that reveals a new protective role miRNAs may play in the successful activation of a pathway. This paper reports the main outcomes of this analysis.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2518694
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