Prevention and successful treatment of implant infection following bone surgery are critical challenges to avoid additional stress, disease, and any extra-surgery to patients. We investigated the feasibility of a new synthesis method to prepare a bioactive glass-ceramic scaffolds doped with silver, an antibacterial element. Scaffolds were fabricated by sponge replication method and silver was incorporated in the glass-based slurry that infiltrates the template using silver nitrate as a precursor. The silver-doped scaffolds mimic closely the cancellous bone in terms of 3-D trabecular architecture and mechanical properties, were highly bioactive as demonstrated by the in vitro formation of a surface hydroxyapatite layer upon soaking in simulated body fluids, and exhibited good antibacterial properties against Staphylococcus aureus, a common bacterial strain involved in postsurgical infections.

Antibacterial Bioglass-Derived Scaffolds: Innovative Synthesis Approach and Characterization / Miola, Marta; Verne', Enrica; VITALE BROVARONE, Chiara; Baino, Francesco. - In: INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE. - ISSN 2041-1286. - ELETTRONICO. - 7:2(2016), pp. 238-247. [10.1111/ijag.12209]

Antibacterial Bioglass-Derived Scaffolds: Innovative Synthesis Approach and Characterization

MIOLA, MARTA;VERNE', ENRICA;VITALE BROVARONE, CHIARA;BAINO, FRANCESCO
2016

Abstract

Prevention and successful treatment of implant infection following bone surgery are critical challenges to avoid additional stress, disease, and any extra-surgery to patients. We investigated the feasibility of a new synthesis method to prepare a bioactive glass-ceramic scaffolds doped with silver, an antibacterial element. Scaffolds were fabricated by sponge replication method and silver was incorporated in the glass-based slurry that infiltrates the template using silver nitrate as a precursor. The silver-doped scaffolds mimic closely the cancellous bone in terms of 3-D trabecular architecture and mechanical properties, were highly bioactive as demonstrated by the in vitro formation of a surface hydroxyapatite layer upon soaking in simulated body fluids, and exhibited good antibacterial properties against Staphylococcus aureus, a common bacterial strain involved in postsurgical infections.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11583/2644443
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